ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate

Base Information

Chemical Name:ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate
CAS No.:1426318-90-2
Molecular Formula:C₁₈H₁₇Cl₂NO₄
Molecular Weight:382.243
Hs Code.:

Synonyms:ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate

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Chemical Property of ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate

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Technology Process of ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate

There total 2 articles about ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 501008-39-5
ethyl 2-((3,5-dichlorophenyl)amino)acetate

: 3282-32-4
2-diazo-acetophenone

: 1426318-90-2
ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate

: C₁₈H₁₇Cl₂NO₄

Guidance literature:: ethyl 2-((3,5-dichlorophenyl)amino)acetate; With (R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; dirhodium tetraacetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

2-diazo-acetophenone; In 1,2-dichloro-ethane; at -10 ℃;

Reference yield:

: 924-44-7
glyoxylic acid ethyl ester

: 3282-32-4
2-diazo-acetophenone

: 626-43-7
3,5-Dichloroaniline

: C₁₈H₁₇Cl₂NO₄

: 1426318-90-2
ethyl (2R,3S)-2-(3,5-dichlorophenylamino)-3-hydroxy-4-oxo-4-phenylbutanoate

Guidance literature:: With dirhodium tetraacetate; (S)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In water; 1,2-dichloro-ethane; at -10 ℃; for 12h; Overall yield = 83 %; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c3cc40546j