methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

Base Information

Chemical Name:methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate
CAS No.:380630-08-0
Molecular Formula:C₂₅H₂₁N₅O₃
Molecular Weight:439.473
Hs Code.:

Synonyms:methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

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Chemical Property of methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

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Technology Process of methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

There total 4 articles about methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 7-(2-naphthylmethyl)guanine hydrochloride

: methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-1H-purin-1-yl]methyl}benzoate

: 380630-08-0
methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

Guidance literature:: 7-(2-naphthylmethyl)guanine hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Methyl 4-(bromomethyl)benzoate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(02)00297-1

Reference yield:

: 118-00-3
G

: 380630-08-0
methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfoxide / 8 h / 20 °C

2.1: 0.59 g / conc. HCl / dimethylsulfoxide / 0.5 h / 20 °C

3.1: NaH / dimethylformamide / 3 h / 20 °C

3.2: 32 percent / dimethylformamide / 3 h / 20 °C

With hydrogenchloride; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00297-1

Reference yield:

: 939-26-4
2-bromomethylnaphthyl bromide

: 380630-08-0
methyl 4-{[2-amino-7-(2-naphthylmethyl)-6-oxo-6,7-dihydro-3H-purin-3-yl]methyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfoxide / 8 h / 20 °C

2.1: 0.59 g / conc. HCl / dimethylsulfoxide / 0.5 h / 20 °C

3.1: NaH / dimethylformamide / 3 h / 20 °C

3.2: 32 percent / dimethylformamide / 3 h / 20 °C

With hydrogenchloride; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00297-1