8H-indeno[1,2-d][1,3]thiazol-2-amine

Base Information

• Chemical Name: 8H-indeno[1,2-d][1,3]thiazol-2-amine
• CAS No.: 85787-95-7
• Molecular Formula: C10H8N2S
• Molecular Weight: 188.253
• Hs Code.: 2934999090
• ChEMBL ID: CHEMBL1178727
• DSSTox Substance ID: DTXSID90525893
• Wikidata: Q82393863
• Mol file: 85787-95-7.mol

Synonyms:8H-indeno[1,2-d][1,3]thiazol-2-amine;85787-95-7;8H-Indeno[1,2-d]thiazol-2-amine;4H-indeno[1,2-d][1,3]thiazol-2-amine;Kinome_3141;F2146-0044;SCHEMBL4959991;CHEMBL1178727;DTXSID90525893;XXHWFLFMSNXBLK-UHFFFAOYSA-N;MFCD08689683;8H-Indeno[1,2-d]thiazol-2-ylamine;AKOS000148236;EA-0736;EN300-52203;F94290;6,8-DIMETHYL-4,5,7-TRIHYDROXYFLAVANONE;AB00808346-02;J-519438;2-Amino-8H-indeno[1,2-d][1,3]thiazole, AldrichCPR;Z240125452

Chemical Property of 8H-indeno[1,2-d][1,3]thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.35E-06mmHg at 25°C
• Melting Point: 268-270 °C
• Refractive Index: 1.753
• Boiling Point: 399.6 °C at 760 mmHg
• PKA: 4.69±0.20(Predicted)
• Flash Point: 195.5 °C
• PSA: 67.15000
• Density: 1.412 g/cm³
• LogP: 2.87770
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 188.04081944
• Heavy Atom Count: 13
• Complexity: 209

Purity/Quality:

97% ^*data from raw suppliers

8H-Indeno[1,2-d][1,3]thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=CC=CC=C2C3=C1SC(=N3)N

Technology Process of 8H-indeno[1,2-d][1,3]thiazol-2-amine

There total 8 articles about 8H-indeno[1,2-d][1,3]thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-chloroindanone (1579-14-2,73908-22-2) + thiourea (17356-08-0) → 2-amino-8H-indeno[1,2-d]thiazole (85787-95-7)

Guidance literature:

With potassium carbonate; at 20 ℃; for 7h; Milling;

DOI:10.1039/c6ob00351f

Reference yield: 63.0%

inden-1-one (83-33-0) + thiourea (17356-08-0) → 2-amino-8H-indeno[1,2-d]thiazole (85787-95-7)

Guidance literature:

inden-1-one; thiourea; With iodine; In ethanol; for 8h; Reflux;

With sodium hydroxide;

DOI:10.1124/mol.114.093286

Reference yield:

8H-indeno[1,2-d]thiazol-2-ylamine hydroiodid → 2-amino-8H-indeno[1,2-d]thiazole (85787-95-7)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 1h;

upstream raw materials:

inden-1-one

thiourea

2-bromoindanone

2-chloroindanone