β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride

Base Information

• Chemical Name: β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride
• CAS No.: 115087-95-1
• Molecular Formula: C₁₉H₁₉N₅O*ClH
• Molecular Weight: 369.854
• Mol file: 115087-95-1.mol

Synonyms:β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride

Chemical Property of β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride

There total 7 articles about β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

[(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride (115087-96-2) → β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride (115087-95-1)

Guidance literature:

With hydrogen; palladium; In methanol; for 24h; Ambient temperature;

DOI:10.1248/cpb.36.1205

Reference yield:

2-amino-2-(4-nitrophenyl)acetic acid (5407-25-0) → β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride (115087-95-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 70 percent

2: catalytic reduction

3: guanidination

4: 86 percent / HCl, formic acid, anisole / dioxane / 20 h / 0 °C

5: 70 percent

6: 35 percent

7: 92 percent / hydrogen / palladium black / methanol / 24 h / Ambient temperature

With hydrogenchloride; formic acid; hydrogen; methoxybenzene; palladium; In 1,4-dioxane; methanol;

DOI:10.1248/cpb.36.1205

Reference yield:

α-t-butoxycarbonylamino-p-aminophenylacetic acid (54895-25-9) → β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride (115087-95-1)

Guidance literature:

Multi-step reaction with 5 steps

1: guanidination

2: 86 percent / HCl, formic acid, anisole / dioxane / 20 h / 0 °C

3: 70 percent

4: 35 percent

5: 92 percent / hydrogen / palladium black / methanol / 24 h / Ambient temperature

With hydrogenchloride; formic acid; hydrogen; methoxybenzene; palladium; In 1,4-dioxane; methanol;

DOI:10.1248/cpb.36.1205

upstream raw materials:

[(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride

2-amino-2-(4-nitrophenyl)acetic acid

α-t-butoxycarbonylamino-p-aminophenylacetic acid

tert-butoxycarbonyl-p-nitro-DL-phenylglycine

Downstream raw materials:

Amino-(4-guanidino-phenyl)-acetic acid