[(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride

Base Information

• Chemical Name: [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride
• CAS No.: 115087-96-2
• Molecular Formula: C₂₇H₂₅N₅O₃*ClH
• Molecular Weight: 503.988
• Mol file: 115087-96-2.mol

Synonyms:[(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride

Chemical Property of [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride

There total 7 articles about [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

Benzyloxycarbonylamino-(4-guanidino-phenyl)-acetic acid (115087-94-0) + naphthalen-2-ylamine (91-59-8) → [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride (115087-96-2)

Guidance literature:

DOI:10.1248/cpb.36.1205

Reference yield:

2-amino-2-(4-nitrophenyl)acetic acid (5407-25-0) → [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride (115087-96-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent

2: catalytic reduction

3: guanidination

4: 86 percent / HCl, formic acid, anisole / dioxane / 20 h / 0 °C

5: 70 percent

6: 35 percent

With hydrogenchloride; formic acid; methoxybenzene; In 1,4-dioxane;

DOI:10.1248/cpb.36.1205

Reference yield:

α-t-butoxycarbonylamino-p-aminophenylacetic acid (54895-25-9) → [(4-Guanidino-phenyl)-(naphthalen-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester; hydrochloride (115087-96-2)

Guidance literature:

Multi-step reaction with 4 steps

1: guanidination

2: 86 percent / HCl, formic acid, anisole / dioxane / 20 h / 0 °C

3: 70 percent

4: 35 percent

With hydrogenchloride; formic acid; methoxybenzene; In 1,4-dioxane;

DOI:10.1248/cpb.36.1205

upstream raw materials:

Benzyloxycarbonylamino-(4-guanidino-phenyl)-acetic acid

naphthalen-2-ylamine

2-amino-2-(4-nitrophenyl)acetic acid

benzyl chloroformate

Downstream raw materials:

β-naphthylamide of p-guanidino-DL-phenylglycine hydrochloride