9-Chloro-2-methoxyacridine

Base Information

• Chemical Name: 9-Chloro-2-methoxyacridine
• CAS No.: 16492-13-0
• Molecular Formula: C14H10ClNO
• Molecular Weight: 243.692
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20497615
• Nikkaji Number: J1.682.615D
• Wikidata: Q82347285
• Mol file: 16492-13-0.mol

Synonyms:9-Chloro-2-methoxyacridine;16492-13-0;Acridine,9-chloro-2-methoxy-;9-chloro-2-methoxy-acridine;Acridine, 9-chloro-2-methoxy-;SCHEMBL13739299;DTXSID20497615;BGAMCDWSLKLEJQ-UHFFFAOYSA-N;AKOS015912116;PS-7540;CS-0361169;D87015

Chemical Property of 9-Chloro-2-methoxyacridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.692
• Boiling Point: 414.912 °C at 760 mmHg
• Flash Point: 204.732 °C
• PSA: 22.12000
• Density: 1.304 g/cm³
• LogP: 4.05000
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 243.0450916
• Heavy Atom Count: 17
• Complexity: 273

Purity/Quality:

99% ^*data from raw suppliers

9-Chloro-2-methoxyacridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C3=CC=CC=C3N=C2C=C1)Cl

Technology Process of 9-Chloro-2-methoxyacridine

There total 14 articles about 9-Chloro-2-methoxyacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(p-methoxyphenyl)anthranilic acid (13501-67-2) → 9-chloro-2-methoxyacridine (16492-13-0)

Guidance literature:

With trichlorophosphate; In i-Amyl alcohol; at 85 - 90 ℃; for 0.25h;

Reference yield: 80.0%

→ 9-chloro-2-methoxyacridine (16492-13-0)

Guidance literature:

With trichlorophosphate; at 100 ℃;

Reference yield: 75.0%

4-methoxy-aniline (104-94-9) + ortho-chlorobenzoic acid (118-91-2) → 9-chloro-2-methoxyacridine (16492-13-0)

Guidance literature:

4-methoxy-aniline; ortho-chlorobenzoic acid; With copper; potassium carbonate; Reflux;

With trichlorophosphate; Reflux;

DOI:10.2174/09298673113209990187

upstream raw materials:

N-(p-methoxyphenyl)anthranilic acid

2-methoxy-phenylamine

ortho-chlorobenzoic acid

4-methoxy-aniline

Downstream raw materials:

toluene-4-sulfonic acid-[N'-(2-methoxy-acridin-9-yl)-hydrazide]; hydrochloride

3-methoxy-9-phenoxyacridine

2-[2-(2-methoxy-acridin-9-ylamino)-ethylamino]-ethanol; dihydrochloride

[4-(2-Methoxy-acridin-9-ylamino)-phenyl]-phosphoramidic acid dimethyl ester; hydrochloride