2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

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Chemical Name:2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid
CAS No.:1443234-67-0
Molecular Formula:C₅₀H₄₆N₄O₂S₅
Molecular Weight:895.271
Hs Code.:

Synonyms:2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

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Chemical Property of 2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

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Technology Process of 2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

There total 6 articles about 2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1443234-66-9
2-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]thiophen-2-yl}-5-[4-hexyl-5-(5-formylthiophen-2-yl)thiophen-2-yl]thiazolo[5,4-d]thiazole

: 372-09-8
cyanoacetic acid

: 1443234-67-0
2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

Guidance literature:: With ammonium acetate; In acetic acid; at 110 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1002/ejoc.201201629

Reference yield:

: 2,5-bis(4-hexyl-5-iodothiophen-2-yl)thiazolo[5,4-d]thiazole

: 1443234-67-0
2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water / 5 h / 90 °C / Schlenk technique; Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium fluoride / toluene; methanol / 0.33 h / 70 °C / Schlenk technique; Inert atmosphere; Microwave irradiation

3: ammonium acetate / acetic acid / 24 h / 110 °C / Schlenk technique; Inert atmosphere

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; sodium carbonate; In methanol; water; acetic acid; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling / 3: |Knoevenagel Condensation;
DOI:10.1002/ejoc.201201629

Reference yield:

: 1443234-65-8
2-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]thiophen-2-yl}-5-(4-hexyl-5-iodothiophen-2-yl)thiazolo[5,4-d]thiazole

: 1443234-67-0
2-cyano-3-{5-[4-hexyl-2-(5-{4-hexyl-5-[4-(diphenylamino)phen-1-yl]-thiophen-2-yl}thiazolo[5,4-d]thiazol-2-yl)thiophen-5-yl]thiophen-2-yl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium fluoride / toluene; methanol / 0.33 h / 70 °C / Schlenk technique; Inert atmosphere; Microwave irradiation

2: ammonium acetate / acetic acid / 24 h / 110 °C / Schlenk technique; Inert atmosphere

With potassium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; In methanol; acetic acid; toluene; 1: |Suzuki Coupling / 2: |Knoevenagel Condensation;
DOI:10.1002/ejoc.201201629