(-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane

Base Information

• Chemical Name: (-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane
• CAS No.: 1032401-65-2
• Molecular Formula: C₂₄H₃₃BrO₂
• Molecular Weight: 433.429
• Mol file: 1032401-65-2.mol

Synonyms:(-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane

Chemical Property of (-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane

There total 2 articles about (-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(+)-(1S,3aS,7aS)-1-tert-butoxy-7a-ethyl-3a,6,7,7a-tetrahydroindane (1032401-55-0) + (Z)-2-(2-iodoethenyl)-4-methoxybromobenzol (213599-26-9) → (-)-(1S,3aS,4S,7aS)-4-(Z)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane (1032401-63-0) + (-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane (1032401-65-2)

Guidance literature:

With silver carbonate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 95 ℃; for 5.33333h;

Reference yield:

(-)-(1S,5S,7aS)-1-tert-butoxy-7a-ethyl-7,7a-dihydroindan-5-yl-formate (1032401-60-7) + (Z)-2-(2-iodoethenyl)-4-methoxybromobenzol (213599-26-9) → C24H33BrO2 + (-)-(1S,3aS,4S,7aS)-4-(Z)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane (1032401-63-0) + (-)-(1S,3aS,4S,7aS)-4(E)-(2-bromo-5-methoxystyryl)-1-tert-butoxy-7a-ethyl-3a,4,7,7a-tetrahydroindane (1032401-65-2)

Guidance literature:

(-)-(1S,5S,7aS)-1-tert-butoxy-7a-ethyl-7,7a-dihydroindan-5-yl-formate; With tributylphosphine; palladium diacetate; In 1,4-dioxane; at 20 - 90 ℃;

(Z)-2-(2-iodoethenyl)-4-methoxybromobenzol; With palladium diacetate; triphenylphosphine; silver carbonate; In N,N-dimethyl-formamide; at 95 ℃;

DOI:10.1002/chem.200700182

upstream raw materials:

(-)-(1S,5S,7aS)-1-tert-butoxy-7a-ethyl-7,7a-dihydroindan-5-yl-formate

(Z)-2-(2-iodoethenyl)-4-methoxybromobenzol

(+)-(1S,3aS,7aS)-1-tert-butoxy-7a-ethyl-3a,6,7,7a-tetrahydroindane