4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Base Information

Chemical Name:4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin
CAS No.:1422963-27-6
Molecular Formula:C₃₄H₃₅N₃O₉
Molecular Weight:629.667
Hs Code.:

Synonyms:4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Suppliers and Price of 4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

There total 3 articles about 4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.12%

: 33143-89-4
1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene

: 155325-17-0
4'-O-trimethyl-4-azido-4-desoxypodophyllotoxin

: 1422963-27-6
4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutylammomium bromide; In tetrahydrofuran; water; at 60 ℃; for 20h;
DOI:10.1002/ardp.201100438

Reference yield:

: 518-28-5
podofilox

: 1422963-27-6
4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; sodium azide / dichloromethane / 25 °C / Cooling with ice

2: copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutylammomium bromide / water; tetrahydrofuran / 20 h / 60 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutylammomium bromide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/ardp.201100438

Reference yield:

: 6214-31-9
3-bromo-3-methylbut-1-yne

: 150-76-5
4-methoxy-phenol

: 1422963-27-6
4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; sodium iodide / acetone / 8 h / 25 °C

2: copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutylammomium bromide / water; tetrahydrofuran / 20 h / 60 °C

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutylammomium bromide; sodium iodide; potassium hydroxide; In tetrahydrofuran; water; acetone;
DOI:10.1002/ardp.201100438