[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

Base Information

Chemical Name:[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester
CAS No.:187976-66-5
Molecular Formula:C₂₈H₄₉N₂O₇P
Molecular Weight:556.68
Hs Code.:

Synonyms:[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

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Chemical Property of [(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

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Technology Process of [(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

There total 4 articles about [(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: ((S)-2-Amino-1-hydroxy-4-methyl-pentyl)-phosphonic acid dibutyl ester; hydrochloride

: 187976-66-5
[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 36h; Yield given;
DOI:10.1021/jm980325e

Reference yield:

: 1809-19-4
dibutyl hydrogen phosphite

: 187976-66-5
[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / KF / dimethylformamide / 24 h / Ambient temperature

2: 4N HCl / dioxane / 2 h

3: HOBt, BOP, NMM / dimethylformamide / 36 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm980325e

Reference yield:

: 58521-45-2
tert-butoxycarbonyl-L-leucinal

: 187976-66-5
[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phosphonic acid dibutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / KF / dimethylformamide / 24 h / Ambient temperature

2: 4N HCl / dioxane / 2 h

3: HOBt, BOP, NMM / dimethylformamide / 36 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm980325e