dicyclooctylamine

Base Information

• Chemical Name: dicyclooctylamine
• CAS No.: 79048-39-8
• Molecular Formula: C₁₆H₃₁N
• Molecular Weight: 237.429
• Mol file: 79048-39-8.mol

Synonyms:dicyclooctylamine

Chemical Property of dicyclooctylamine

Chemical Property:

Purity/Quality:

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Technology Process of dicyclooctylamine

There total 1 articles about dicyclooctylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cycloactanone (502-49-8) → cyclooctanol (696-71-9) + dicyclooctylamine (79048-39-8) + cyclooctylamine (5452-37-9)

Guidance literature:

With ammonia; hydrogen; In o-xylene; at 80 ℃; for 20h; Autoclave;

DOI:10.1002/cctc.201402996

Reference yield: 65.0%

dicyclooctylamine (79048-39-8) + C14H18F3N3S + phenylcarbonochloridothioate (1005-56-7) → 1,1-dicyclooctyl-3-((1R,2R)-2-(3-(4-(trifluoromethyl)phenyl)thioureido)cyclohexyl)thiourea

Guidance literature:

C₁₄H₁₈F₃N₃S; phenylcarbonochloridothioate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

dicyclooctylamine; In tetrahydrofuran; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.6b05225

Reference yield: 61.0%

1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea (860994-58-7) + dicyclooctylamine (79048-39-8) + phenylcarbonochloridothioate (1005-56-7) → 3-((1R,2R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)cyclohexyl)-1,1-dicyclooctylthiourea

Guidance literature:

1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; phenylcarbonochloridothioate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

dicyclooctylamine; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jacs.6b05225

upstream raw materials:

cycloactanone

Refernces