{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

Base Information

Chemical Name:{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate
CAS No.:1345983-30-3
Molecular Formula:C₂HF₃O₂*C₂₅H₃₆NO₆PS
Molecular Weight:623.628
Hs Code.:

Synonyms:{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

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Chemical Property of {[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

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Technology Process of {[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

There total 20 articles about {[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.2%

: 1345983-77-8
diethyl {[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonate

: 76-05-1
trifluoroacetic acid

: 1345983-30-3
{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

Guidance literature:: diethyl {[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonate; With trimethylsilyl bromide; In dichloromethane; at 25 ℃; for 15h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 98-88-4
benzoyl chloride

: 1345983-30-3
{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 13 steps

1.1: trifluorormethanesulfonic acid / dichloromethane / 49 h / 5 - 20 °C / Reflux

2.1: boron trichloride / dichloromethane / 0.5 h / 0 - 5 °C

2.2: 0.5 h / 10 °C

2.3: 0.5 h / 15 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

3.2: 3 h / 60 °C

4.1: diphenylether / 4.5 h / 215 °C

5.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

5.2: 15 h / 85 °C

6.1: citric acid / toluene / 50 h / 130 °C / Reflux

7.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

8.2: 0.5 h

9.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

10.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C

10.2: 1 h / pH 12 / Cooling with ice

11.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C

12.1: toluene / 18 h / 25 °C / Reflux

13.1: trimethylsilyl bromide / dichloromethane / 15 h / 25 °C

With 1H-imidazole; lithium aluminium tetrahydride; borane-THF; trimethylsilyl bromide; trifluorormethanesulfonic acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; dihydrogen peroxide; bromine; boron trichloride; triethylamine; triphenylphosphine; trifluoroacetic acid; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; diphenylether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 616-06-8
2-amino-hexanoic acid

: 1345983-30-3
{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 15 steps

1.1: thionyl chloride / 0 - 65 °C

2.1: magnesium sulfate; triethylamine / dichloromethane / 2 h / 25 °C

2.2: 0.5 h

2.3: 60 h / 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 25 °C

3.2: 20 h / 25 °C

4.1: hydrogenchloride; water / 0.5 h / 25 °C

4.2: 0 °C / pH 12

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 65 °C

5.2: 2 h / 0 °C

6.1: chlorosulfonic acid / ethyl acetate / 3 h / 25 - 40 °C

7.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

7.2: 15 h / 85 °C

8.1: citric acid / toluene / 50 h / 130 °C / Reflux

9.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

10.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

10.2: 0.5 h

11.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

12.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C

12.2: 1 h / pH 12 / Cooling with ice

13.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C

14.1: toluene / 18 h / 25 °C / Reflux

15.1: trimethylsilyl bromide / dichloromethane / 15 h / 25 °C

With 1H-imidazole; hydrogenchloride; chlorosulfonic acid; lithium aluminium tetrahydride; thionyl chloride; borane-THF; trimethylsilyl bromide; 1,3-bis-(diphenylphosphino)propane; water; dihydrogen peroxide; bromine; sodium hydride; magnesium sulfate; triethylamine; triphenylphosphine; trifluoroacetic acid; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;