(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

Base Information

Chemical Name:(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid
CAS No.:1313216-09-9
Molecular Formula:C₂₆H₃₂N₄O₄S
Molecular Weight:496.63
Hs Code.:

Synonyms:(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

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Chemical Property of (6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

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Technology Process of (6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

There total 8 articles about (6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1313217-07-0
tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

: 1313216-09-9
(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

Guidance literature:: tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h;

With hydrogenchloride; sodium hydroxide; In water; pH=4.4;

Reference yield:

: 3006-96-0
3-hydroxymethyl-benzoic acid

: 1313216-09-9
(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.25 h / Cooling with ice

1.2: pH 7.5

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

2.2: 20 °C / Cooling with ice

3.1: magnesium / tetrahydrofuran / 20 °C / Cooling with ice

4.1: n-butyllithium / hexane; tetrahydrofuran / -70 - 20 °C

4.2: 3 h / 20 °C

5.1: hydrogen / platinum(IV) oxide / ethanol / 6 h / 20 °C / 760.05 Torr

6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 16 h / 20 °C

7.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

8.2: pH 4.4

With n-butyllithium; tributylphosphine; diamide; water; hydrogen; sodium hydride; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1313217-85-4
1-[4-(4-methoxybenzyloxymethyl)phenyl]pentan-1-one

: 1313216-09-9
(6-{[4-(1-methylpentyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-ylamino)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -70 - 20 °C

1.2: 3 h / 20 °C

2.1: hydrogen / platinum(IV) oxide / ethanol / 6 h / 20 °C / 760.05 Torr

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 16 h / 20 °C

4.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

5.2: pH 4.4

With n-butyllithium; tributylphosphine; diamide; water; hydrogen; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane; dichloromethane;