Technology Process of 1-(((1-Phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene
There total 9 articles about 1-(((1-Phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
at 20 ℃;
for 12h;
under 2585.81 Torr;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 9 steps
1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark
2: diisobutylaluminium hydride / toluene / 2 h / -78 °C
3: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C
4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C
5: hydrogenchloride / water; acetone / 1 h / Reflux
6: sodium tetrahydroborate / methanol / 0.17 h / 20 °C
7: pyridine / 3 h / 0 - 20 °C
8: 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap / benzene / 12 h / 80 °C
9: hydrogen; palladium 10% on activated carbon / 12 h / 20 °C / 2585.81 Torr
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C
3: hydrogenchloride / water; acetone / 1 h / Reflux
4: sodium tetrahydroborate / methanol / 0.17 h / 20 °C
5: pyridine / 3 h / 0 - 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap / benzene / 12 h / 80 °C
7: hydrogen; palladium 10% on activated carbon / 12 h / 20 °C / 2585.81 Torr
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; mineral oil; benzene;
DOI:10.1016/j.bmc.2013.02.010
