1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

Base Information

Chemical Name:1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene
CAS No.:1429045-52-2
Molecular Formula:C₂₂H₂₀F₆O
Molecular Weight:414.391
Hs Code.:

Synonyms:1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

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Chemical Property of 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

Chemical Property:

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Technology Process of 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

There total 8 articles about 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylcyclohexyl methanesulfonate

: 1429045-52-2
1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

Guidance literature:: With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; at 80 ℃; for 12h;
DOI:10.1016/j.bmc.2013.02.010

Reference yield:

: 51509-98-9
8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril

: 1429045-52-2
1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 7 steps

1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

4: hydrogenchloride / water; acetone / 1 h / Reflux

5: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

6: pyridine / 3 h / 0 - 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap / benzene / 12 h / 80 °C

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene;
DOI:10.1016/j.bmc.2013.02.010

Reference yield:

: 25115-74-6
4-cyano-4-phenylcyclohexanone

: 1429045-52-2
1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 8 steps

1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark

2: diisobutylaluminium hydride / toluene / 2 h / -78 °C

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

5: hydrogenchloride / water; acetone / 1 h / Reflux

6: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

7: pyridine / 3 h / 0 - 20 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap / benzene / 12 h / 80 °C

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene;
DOI:10.1016/j.bmc.2013.02.010