Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester

Base Information

• Chemical Name: Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester
• CAS No.: 66111-51-1
• Molecular Formula: C₂₁H₃₁N₃O₆
• Molecular Weight: 421.494
• Mol file: 66111-51-1.mol

Synonyms:Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester

Chemical Property of Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester

There total 3 articles about Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-(tert-butoxycarbonyl)-L-α-aminobutanoyl-D-isoglutamine (112302-94-0) → Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester (66111-51-1)

Guidance literature:

With N-cyclohexyl-cyclohexanamine; In N,N-dimethyl-formamide; at 70 ℃; for 2h;

DOI:10.1016/0008-6215(87)80165-9

Reference yield:

Boc-Abu (34306-42-8) → Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester (66111-51-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide / ethyl acetate / 1 h / 0 °C

2: 46 percent / 2 M NaOH / dioxane; H₂O / 20 h / Ambient temperature

3: 79 percent / dicyclohexylamine / dimethylformamide / 2 h / 70 °C

With sodium hydroxide; N-cyclohexyl-cyclohexanamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/0008-6215(87)80165-9

Reference yield:

(S)-2-tert-Butoxycarbonylamino-butyric acid 4-nitro-phenyl ester (67708-97-8) → Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester (66111-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / 2 M NaOH / dioxane; H₂O / 20 h / Ambient temperature

2: 79 percent / dicyclohexylamine / dimethylformamide / 2 h / 70 °C

With sodium hydroxide; N-cyclohexyl-cyclohexanamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/0008-6215(87)80165-9

upstream raw materials:

N-(tert-butoxycarbonyl)-L-α-aminobutanoyl-D-isoglutamine

Boc-Abu

(S)-2-tert-Butoxycarbonylamino-butyric acid 4-nitro-phenyl ester

Downstream raw materials:

L-α-Aminobutanoyl-D-isoglutamine benzyl ester

L-α-aminobutanoyl-D-isoglutamine benzyl ester

L-2-Aminobutanoyl-D-isoglutamine benzyl ester trifluoroacetate