BOC-ABU-ONP

Base Information

• Chemical Name: BOC-ABU-ONP
• CAS No.: 67708-97-8
• Molecular Formula: C₁₅H₂₀N₂O₆
• Molecular Weight: 324.334
• Mol file: 67708-97-8.mol

Synonyms:Boc-L-α-aminobutyricacid4-nitrophenylester;BOC-L-ALPHA-AMINOBUTYRIC ACID 4-NITROPHENYL ESTER;BOC-L-2-AMINOBUTANOIC ACID 4-NITROPHENYL ESTER;03941 BOC-L-α-AMINOBUTYRIC ACID 4-NITROPHENYL ESTER;Boc-L-Alpha-aminobutyricacid4-nitrophenylester;03941 BOC-L-ALPHA-AMINOBUTYRIC ACID 4-NITROPHENYL ESTER;(S)-2-tert-Butoxycarbonylamino-butyric acid 4-nitro-phenyl ester;BOC-ABU-ONP;BOC-L-α-AMINOBUTYRIC ACID 4-NITROPHENYL ESTER;

Chemical Property of BOC-ABU-ONP

Chemical Property:

• PSA: 110.45000
• LogP: 3.71760
• Storage Temp.: Store at 0°C

Purity/Quality:

≥ 97% (HPLC) ^*data from raw suppliers

Boc-L-alpha-aminobutyric acid 4-nitrophenyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-ABU-ONP

There total 1 articles about BOC-ABU-ONP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Boc-Abu (34306-42-8) → (S)-2-tert-Butoxycarbonylamino-butyric acid 4-nitro-phenyl ester (67708-97-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 ℃; for 1h;

DOI:10.1016/0008-6215(87)80165-9

Reference yield:

(S)-2-tert-Butoxycarbonylamino-butyric acid 4-nitro-phenyl ester (67708-97-8) → Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester (66111-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / 2 M NaOH / dioxane; H₂O / 20 h / Ambient temperature

2: 79 percent / dicyclohexylamine / dimethylformamide / 2 h / 70 °C

With sodium hydroxide; N-cyclohexyl-cyclohexanamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/0008-6215(87)80165-9

upstream raw materials:

4-nitro-phenol

Boc-Abu

Downstream raw materials:

Tert-butoxycarbonyl-L-2-aminobutanoyl-D-isoglutamine benzyl ester