hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester

Base Information

• Chemical Name: hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester
• CAS No.: 321983-71-5
• Molecular Formula: C₃₂H₄₈N₄O₅
• Molecular Weight: 568.757
• Mol file: 321983-71-5.mol

Synonyms:hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester

Chemical Property of hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester

There total 12 articles about hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-Hexen-1-ol (821-41-0) + (S)-1-[(S)-2-((S)-2-Hept-6-enoylamino-3-methyl-butyrylamino)-3-phenyl-propionyl]-hexahydro-pyridazine-3-carboxylic acid → hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester (321983-71-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/ja021327y

Reference yield:

(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester → hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester (321983-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: aq. LiOH / tetrahydrofuran

3: 60 percent / Ph₃P; DEAD / tetrahydrofuran

With lithium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 3: Mitsunobu reaction;

DOI:10.1021/ja021327y

Reference yield:

(tert-butoxycarbonyl)-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic asid methyl ester (247186-16-9) → hept-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester (321983-71-5)

Guidance literature:

Multi-step reaction with 4 steps

1: TFA / CH₂Cl₂ / 2 h / 0 °C

2: tetrahydrofuran

3: aq. LiOH / tetrahydrofuran

4: 60 percent / Ph₃P; DEAD / tetrahydrofuran

With lithium hydroxide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 4: Mitsunobu reaction;

DOI:10.1021/ja021327y

upstream raw materials:

5-Hexen-1-ol

hept-6-enoic acid

(tert-butoxycarbonyl)-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic asid methyl ester

hept-6-en-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid methyl ester

Downstream raw materials:

(E)-(3S,6S,21S)-3-benzyl-6-isopropyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]-pentacos-13-ene-2,5,8,20-tetraone