7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Base Information

Chemical Name:7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one
CAS No.:903504-30-3
Molecular Formula:C₁₆H₁₈O₃S
Molecular Weight:290.383
Hs Code.:

7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3<i>H</i>-isobenzofuran-1-one

Synonyms:7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Suppliers and Price of 7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

There total 6 articles about 7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 903504-29-0
6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

: 903504-30-3
7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Guidance literature:: 6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

With oxygen; triethyl phosphite; In tetrahydrofuran; at -78 ℃;
DOI:10.1002/anie.200601116

Reference yield:

: 903504-28-9
(2R,3E,5E)-1-(phenylthio)hepta-3,5-dien-2-ol

: 903504-30-3
7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-(pyrrolidin-1-yl)phenol; MeMgBr / toluene; diethyl ether / 1.5 h / 4 °C

1.2: toluene; diethyl ether / 18 h / 55 °C

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: O₂ (gas); (EtO)3P / tetrahydrofuran

With 2-(pyrrolidin-1-yl)phenol; methylmagnesium bromide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; toluene; 1.2: Diels-Alder reaction;
DOI:10.1021/ja067083p

Reference yield:

: 903504-38-1
(3E,5E)-1-(phenylthio)hepta-3,5-dien-2-one

: 903504-30-3
7a-hydroxy-6-methyl-3-phenylsulfanylmethyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; catecholborane / CH₂Cl₂; toluene / 12 h / -78 °C

2.1: 2-(pyrrolidin-1-yl)phenol; MeMgBr / toluene; diethyl ether / 1.5 h / 4 °C

2.2: toluene; diethyl ether / 18 h / 55 °C

3.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: O₂ (gas); (EtO)3P / tetrahydrofuran

With 2-(pyrrolidin-1-yl)phenol; methylmagnesium bromide; lithium hexamethyldisilazane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 2.2: Diels-Alder reaction;
DOI:10.1021/ja067083p