C₄₅H₄₉F₂N₇O₁₆

Base Information

Chemical Name:C₄₅H₄₉F₂N₇O₁₆
CAS No.:178744-34-8
Molecular Formula:C₄₅H₄₉F₂N₇O₁₆
Molecular Weight:981.918
Hs Code.:

C<sub>45</sub>H<sub>49</sub>F<sub>2</sub>N<sub>7</sub>O<sub>16</sub>

Synonyms:C₄₅H₄₉F₂N₇O₁₆

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₄₅H₄₉F₂N₇O₁₆

Chemical Property:

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Technology Process of C₄₅H₄₉F₂N₇O₁₆

There total 21 articles about C₄₅H₄₉F₂N₇O₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 178744-44-0
(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-propionic acid

: (S)-2-[(R)-2-[(R)-2-Amino-2-(3,5-dihydroxy-4-methoxy-phenyl)-acetylamino]-2-(4-methoxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester; hydrochloride

: 178744-34-8
C₄₅H₄₉F₂N₇O₁₆

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1039/cc9960001029 DOI:10.1055/s-1997-722

Reference yield:

: 918446-55-6
(3,5-Diisopropoxy-4-methoxy-phenyl)-methanol

: 178744-34-8
C₄₅H₄₉F₂N₇O₁₆

Guidance literature:: Multi-step reaction with 12 steps

1: 90 percent / PBr₃ / toluene

2: 97 percent / dimethylsulfoxide

3: 94 percent / K₂CO₃, H₂O₂ / dimethylsulfoxide

4: 88 percent / KOH / ethane-1,2-diol

5: 1.) Me₃CCOCl, Et₃N / 1.) THF

6: 1.) KHDMS, trisyl-N₃, 2.) NaI, NaOAc / 1.) THF, 2.) Me₂SO

7: H₂ / 10percent Pd/C

8: ethyl acetate

9: 90 percent / aq. LiOH / tetrahydrofuran

10: EDC, HOBt, Et₃N / CH₂Cl₂

11: 1.) BCl₃ / 1.) CH₂Cl₂, 2.) MeOH

12: 65 percent / EDC, HOBt, Et₃N / CH₂Cl₂

With potassium hydroxide; lithium hydroxide; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; sodium acetate; pivaloyl chloride; boron trichloride; phosphorus tribromide; potassium hexamethylsilazane; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethylene glycol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1039/cc9960001029

Reference yield:

: 171738-31-1
4-methoxy-3,5-diisopropyloxybenzaldehyde

: 178744-34-8
C₄₅H₄₉F₂N₇O₁₆

Guidance literature:: Multi-step reaction with 13 steps

1: 92 percent / NaBH₄ / ethanol

2: 90 percent / PBr₃ / toluene

3: 97 percent / dimethylsulfoxide

4: 94 percent / K₂CO₃, H₂O₂ / dimethylsulfoxide

5: 88 percent / KOH / ethane-1,2-diol

6: 1.) Me₃CCOCl, Et₃N / 1.) THF

7: 1.) KHDMS, trisyl-N₃, 2.) NaI, NaOAc / 1.) THF, 2.) Me₂SO

8: H₂ / 10percent Pd/C

9: ethyl acetate

10: 90 percent / aq. LiOH / tetrahydrofuran

11: EDC, HOBt, Et₃N / CH₂Cl₂

12: 1.) BCl₃ / 1.) CH₂Cl₂, 2.) MeOH

13: 65 percent / EDC, HOBt, Et₃N / CH₂Cl₂

With potassium hydroxide; lithium hydroxide; sodium tetrahydroborate; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; sodium acetate; pivaloyl chloride; boron trichloride; phosphorus tribromide; potassium hexamethylsilazane; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethylene glycol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1039/cc9960001029