3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid

Base Information

Chemical Name:3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid
CAS No.:232595-59-4
Molecular Formula:C₁₂H₁₅NO₅
Molecular Weight:253.255
Hs Code.:2924299090
European Community (EC) Number:630-150-8
DSSTox Substance ID:DTXSID90592787
Wikidata:Q82487085
Mol file:232595-59-4.mol

Synonyms:232595-59-4;3-(N-Boc-amino)-5-hydroxybenzoic Acid;3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid;3-[(tert-Butoxycarbonyl)amino]-5-hydroxybenzoic acid;3-hydroxy-5-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid;MFCD02682202;Benzoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-hydroxy-;3-Amino-5-hydroxybenzoic acid, N-BOC protected;SCHEMBL2178704;DTXSID90592787;KSTCXQVSGVVIAO-UHFFFAOYSA-N;AMY39913;AC1652;AKOS016007297;3-(N-Boc-amino)-5-hydroxybenzoicAcid;AC-2629;CS-11010;SY002341;DB-012796;CS-0371728;EN300-763959;3-tert-butoxycarbonylamino-5-hydroxy-benzoic acid;A878291;3-{[(tert-butoxy)carbonyl]amino}-5-hydroxybenzoic acid

Suppliers and Price of 3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(N-Boc-Amino)-5-hydroxybenzoicAcid
500mg
$ 175.00

SynQuest Laboratories
3-Amino-5-hydroxybenzoic acid, N-Boc protected 95%
1 g
$ 218.00

Labseeker
3-(N-Boc-Amino)-5-hydroxybenzoicAcid 95
5g
$ 700.00

Crysdot
3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoicacid 95+%
10g
$ 425.00

American Custom Chemicals Corporation
3-AMINO-5-HYDROXY BENZOIC ACID, N-BOC PROTECTED 95.00%
1G
$ 775.43

Alichem
3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoicacid
10g
$ 998.00

AK Scientific
3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoicacid
5g
$ 424.00

AK Scientific
3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoicacid
1g
$ 181.00

Total 31 raw suppliers

Chemical Property of 3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid

Chemical Property:

Vapor Pressure:5.66E-07mmHg at 25°C
Melting Point:150 °C
Refractive Index:1.601
Boiling Point:395.8 °C at 760 mmHg
PKA:4.03±0.10(Predicted)
Flash Point:193.1 °C
PSA：95.86000
Density:1.337 g/cm³
LogP:2.51040
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:253.09502258
Heavy Atom Count:18
Complexity:323

Purity/Quality:

97% ^*data from raw suppliers

3-(N-Boc-Amino)-5-hydroxybenzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=CC(=CC(=C1)C(=O)O)O
Uses 3-(N-Boc-Amino)-5-hydroxybenzoic Acid is used as a reactant in the preparation of thiazolecarboxamides as vitronectin receptor antagonists.

Technology Process of 3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid

There total 4 articles about 3-((tert-Butoxycarbonyl)amino)-5-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 14206-69-0
3-amino-5-hydroxybenzoic acid hydrochloride

: 232595-59-4
3-tert-butoxycarbonylamino-5-hydroxy-benzoic acid

Guidance literature:: di-tert-butyl dicarbonate; 3-amino-5-hydroxybenzoic acid hydrochloride; With sodium hydrogencarbonate; sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h;

With hydrogenchloride; In water;

Reference yield:

: 99-10-5
3,5-Dihydroxybenzoic acid

: 232595-59-4
3-tert-butoxycarbonylamino-5-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium hydroxide; ammonium chloride / 72 h / 180 °C / Autoclave

1.2: 24 h / 100 °C

2.1: sodium hydrogencarbonate; sodium hydroxide / 1,4-dioxane; water / 12 h / 20 °C

With ammonium hydroxide; sodium hydrogencarbonate; ammonium chloride; sodium hydroxide; In 1,4-dioxane; water;