76045-71-1

Basic information

• Product Name: 3-AMINO-5-HYDROXYBENZOIC ACID
• Synonyms: 3-AMINO-5-HYDROXYBENZOIC ACID;Benzoic acid, 3-amino-5-hydroxy- (9CI);Benzoic acid, 3-amino-5-hydroxy-;5-AMINO-3-HYDROXYBENZOIC ACID;3-Hydroxy-5-aminobenzoic acid;3-amino-5-hydrobenzoic acid
• CAS NO: 76045-71-1
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Product Categories: CARBOXYLICACID
• Mol File: 76045-71-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 242 °C
• Boiling Point: 453.4 °C at 760 mmHg
• Flash Point: 228 °C
• Appearance: /
• Density: 1.491 g/cm³
• Vapor Pressure: 5.2E-09mmHg at 25°C
• Refractive Index: 1.691
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.33±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-HYDROXYBENZOIC ACID(76045-71-1)
• EPA Substance Registry System: 3-AMINO-5-HYDROXYBENZOIC ACID(76045-71-1)

Safety Data

• Hazardous Substances Data: 76045-71-1(Hazardous Substances Data)

Usage

Uses

3-Amino-5-hydroxybenzoic Acid is used in preparation of Meta-azacyclic Amino Benzoic Acid derivative as pan integrin antagonists useful in treating diseases.

Definition

ChEBI: A monohydroxybenzoic acid that is 3-hydroxybenzoic acid carrying an additional amino substitutent at position 4.

InChI:InChI=1/C7H7NO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,8H2,(H,10,11)

Upstream product

• 141726-22-9 5-deoxy-5-amino-3-dehydroshikimic acid 
• 3615-55-2 D-ribose 5-phosphate 
• 138-08-9 phosphoenolpyruvic acid 
• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 65-85-0 benzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 
• 618-84-8 3-amino-5-nitro-benzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 78238-13-8 3-methoxy-5-nitrobenzoic acid methyl ester 
• 2702-58-1 methyl 3,5-dinitrobenzoate 
• 14206-69-0 3-amino-5-hydroxybenzoic acid hydrochloride 
• 78238-14-9 3-hydroxy-5-nitrobenzoic acid 

Downstream Products

• 1266683-63-9 3-azido-5-hydroxybenzoic acid 
• 1266683-64-0 methyl 3-azido-5-hydroxybenzoate 
• 1266683-65-1 methyl 3-azido-5-isobutoxybenzoate 
• 1266683-66-2 methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate 
• 1266683-67-3 C₂₈H₃₅ClN₄O₅ 
• 1266683-53-7 C₅₂H₆₄N₈O₉ 
• 1266683-56-0 C₃₈H₄₈BrN₅O₆ 
• 240431-49-6 3-hydroxy-5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]benzoic acid 
• 1445788-80-6 3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid 
• 1116009-43-8 C₂₁H₂₄N₂O₉ 
• 1116009-63-2 C₁₅H₂₀N₂O₈ 
• 1116009-51-8 C₁₈H₂₆N₂O₉ 
• 900799-69-1 3-Benzyloxycarbonylamino-5-hydroxy-benzoic acid 

Relevant articles and documents

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin c

Beyond the identification of 3-amino-5-hydroxybenzoic acid (AHBA) and D-glucosamine as biosynthetic precursors to mitomycin C (5) and FR900482 (6), little is known about the pathway Nature uses to prepare these antitumor antibiotics. To gain some insight

Kanosamine biosynthesis: A likely source of the aminoshikimate pathway's nitrogen atom

The biosynthetic source of the nitrogen atom incorporated into the aminoshikimate pathway has remained a question for some time. 3-Amino-3-deoxy-d-fructose 6-phosphate has previously been demonstrated to be a precursor to 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate and 3-amino-5-hydroxybenzoic acid via the inferred intermediacy of 1-deoxy-1-imino-d-erythrose 4-phosphate in Amycolatopsis mediterranei cell-free extract. This investigation examines the possibility that the natural product kanosamine might be a precursor to 3-amino-3-deoxy-d-fructose 6-phosphate. Kanosamine 6-phosphate was synthesized by a chemoenzymatic route and incubated in A. mediterranei cell-free lysate along with d-ribose 5-phosphate and phosphoenolpyruvate. Formation of 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate and 3-amino-5-hydroxybenzoic acid was observed. Subsequent incubation in A. mediterranei cell-free lysate of glutamine and NAD with UDP-glucose resulted in the formation of kanosamine. The bioconversion of UDP-glucose into kanosamine along with the bioconversion of kanosamine 6-phosphate into 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate and 3-amino-5-hydroxybenzoic acid suggests that kanosamine biosynthesis is the source of the aminoshikimate pathway's nitrogen atom. Copyright