2-Hydrazinyl-6-methoxybenzo[d]thiazole

Base Information

• Chemical Name: 2-Hydrazinyl-6-methoxybenzo[d]thiazole
• CAS No.: 20174-70-3
• Molecular Formula: C8H9N3OS
• Molecular Weight: 195.245
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20365769
• Wikidata: Q82150717
• ChEMBL ID: CHEMBL1241419
• Mol file: 20174-70-3.mol

Synonyms:20174-70-3;2-Hydrazinyl-6-methoxybenzo[d]thiazole;2-hydrazino-6-methoxy-1,3-benzothiazole;(6-Methoxybenzothiazol-2-yl)-hydrazine;2-hydrazinyl-6-methoxy-1,3-benzothiazole;(6-methoxy-1,3-benzothiazol-2-yl)hydrazine;(6-Methoxy-benzothiazol-2-yl)-hydrazine;Benzothiazole,2-hydrazinyl-6-methoxy-;2(3H)-Benzothiazolone, 6-methoxy-, hydrazone;Oprea1_150964;SCHEMBL2114859;CHEMBL1241419;DTXSID20365769;2-hydrazino-6-methoxybenzothiazole;6-methoxy 2-hydrazino benzothiazole;BBL000140;MFCD01439956;STK507131;AKOS000113997;HA-0925;6-Methoxy-1,3-benzothiazol-2-yl)hydrazine;BB 0246093;FT-0681094;1-(6-Methoxybenzo[d] thiazol-2-yl)hydrazine;EN300-236090;2-hydrazino-1,3-benzothiazol-6-yl methyl ether;A846465;J-509585;F1908-0014;2(3H)-Benzothiazolone,6-methoxy-,hydrazone(9CI);2-hydrazino-6-methoxy-1,3-benzothiazole (en)

Chemical Property of 2-Hydrazinyl-6-methoxybenzo[d]thiazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 164-167 °C
• Refractive Index: 1.75
• Boiling Point: 364.7 °C at 760 mmHg
• PKA: 2.69±0.20(Predicted)
• Flash Point: 174.4 °C
• PSA: 88.41000
• Density: 1.426 g/cm³
• LogP: 2.36380
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 195.04663309
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

2-Hydrazino-6-methoxy-1,3-benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C(S2)NN

Technology Process of 2-Hydrazinyl-6-methoxybenzo[d]thiazole

There total 9 articles about 2-Hydrazinyl-6-methoxybenzo[d]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

6-methoxybenzothiazol-2-ylamine (1747-60-0) → 2-hydrazinyl-6-methoxybenzo[d]thiazole (20174-70-3)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In ethylene glycol; Microwave irradiation;

DOI:10.1002/jhet.1618

Reference yield:

4-methoxy-aniline (104-94-9) → 2-hydrazinyl-6-methoxybenzo[d]thiazole (20174-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia; bromine; acetic acid

2: hydrogenchloride; hydrazine hydrate / water; ethylene glycol / Reflux

With hydrogenchloride; ammonia; bromine; hydrazine hydrate; acetic acid; In water; ethylene glycol;

DOI:10.1002/ardp.201000061

Reference yield:

1-(4-methoxyphenyl)thiourea (2293-07-4) → 2-hydrazinyl-6-methoxybenzo[d]thiazole (20174-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂

2: NH₂NH₂*H₂O

With bromine; hydrazine hydrate;

upstream raw materials:

6-methoxybenzothiazol-2-ylamine

4-methoxy-aniline

1-(4-methoxyphenyl)thiourea

2-chloro-6-(methyloxy)-1,3-benzothiazole

Downstream raw materials:

2-(6-Methoxy-benzothiazol-2-yl)-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(6-methoxy-2-benzothiazolyl)pyrazole

C₁₅H₁₃ClN₄OS₂

C₁₅H₁₃FN₄OS₂