1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

Base Information

Chemical Name:1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea
CAS No.:1442473-64-4
Molecular Formula:C₃₃H₃₀ClF₂N₅O₃
Molecular Weight:618.083
Hs Code.:

Synonyms:1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

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Chemical Property of 1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

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Technology Process of 1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

There total 13 articles about 1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1442470-93-0
prop-1-en-2-yl (4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)carbamate

: 52215-41-5
3-fluoro-5-methylaniline

: 1442473-64-4
1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃;

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 1442473-64-4
1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

Guidance literature:: Multi-step reaction with 9 steps

1: 2 h / 120 °C

2: trichlorophosphate / 2 h / Reflux

3: water; acetonitrile / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -50 - 0 °C

5: manganese(IV) oxide / dichloromethane / 20 °C

6: potassium fluoride on basic alumina / N,N-dimethyl acetamide / 0.17 h / 20 °C

7: 200 °C / Sealed tube

8: ethyl acetate / 3 h / 20 °C

9: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium fluoride on basic alumina; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; acetonitrile;

Reference yield:

: 177985-32-9
2-(2-chloro-4-fluorophenyl)acetic acid

: 1442473-64-4
1-(4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(3-fluoro-5-methylphenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; sulfuric acid / 0.17 h / -10 - 0 °C

2: sulfuryl dichloride / 1 h / Reflux

3: hydrogen / water; ethanol / 5 h / 1551.49 Torr

4: potassium fluoride on basic alumina / N,N-dimethyl acetamide / 0.17 h / 20 °C

5: 200 °C / Sealed tube

6: ethyl acetate / 3 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

With sulfuryl dichloride; sulfuric acid; potassium fluoride on basic alumina; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; water; ethyl acetate;