3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

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Chemical Name:3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride
CAS No.:714218-77-6
Molecular Formula:C₂₀H₂₈N₆O₄S*ClH
Molecular Weight:485.007
Hs Code.:

Synonyms:3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

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Chemical Property of 3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

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Technology Process of 3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

There total 5 articles about 3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 3-amino-6-bromo-N-(3-methoxypropyl)pyrazine-2-carboxamide

: 714218-77-6
3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

Guidance literature:: 1-((4-bromophenyl)sulfonyl)-4-methylpiperazine; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 0.333333h;

With hydrogenchloride; In tetrahydrofuran; water; for 0.166667h;

3-amino-6-bromo-N-(3-methoxypropyl)pyrazine-2-carboxamide; With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; more than 3 stages;

Reference yield: 19.0%

: 486422-11-1
4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid

: 3-amino-6-bromo-N-(3-methoxypropyl)pyrazine-2-carboxamide

: 714218-77-6
3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

Guidance literature:: 4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid; 3-amino-6-bromo-N-(3-methoxypropyl)pyrazine-2-carboxamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In tetrahydrofuran; water; at 70 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane; Microwave irradiation;
DOI:10.1021/jm201724m

Reference yield:

: 52833-94-0
2-amino-5-bromonicotinicacid

: 714218-77-6
3-amino-N-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-ethanamine; 1-hydroxy-1H-benzotriazol hydrate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / tetrahydrofuran; water / 70 °C

2.2: Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-ethanamine; 1-hydroxy-1H-benzotriazol hydrate; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;
DOI:10.1021/jm201724m