(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

Base Information

Chemical Name:(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate
CAS No.:1071476-56-6
Molecular Formula:C₃₂H₄₁F₃N₂O₈
Molecular Weight:638.681
Hs Code.:

(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

Synonyms:(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

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Chemical Property of (2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

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Technology Process of (2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

There total 1 articles about (2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 1071476-03-3
(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

: 1071476-56-6
(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 1071476-56-6
(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

: 1071477-16-1
C₂₂H₂₅F₃N₂O₅*ClH

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 23 ℃; for 4h;

Reference yield:

: 1071476-56-6
(2S)-methyl 2-((2S)-2-(tert-butoxycarbonylamino)-3-(4-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

: 1071476-61-3
(S)-methyl 2-((S)-2-(4-((2-(N-(bis(4-methoxyphenylxphenyl)methyl)sulfamoyl)benzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(tert-butoxycarbonyl)-3-(4-(2-(tosyloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 4 h / 23 °C

2: pyridine; sodium azide; trifluoromethylsulfonic anhydride; copper(II) sulfate / water / 0 - 23 °C

3: triethylamine / dichloromethane / 0.33 h / 0 °C

4: dmap / acetonitrile / 23 °C

5: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 23 °C

With pyridine; hydrogenchloride; dmap; copper(l) iodide; sodium azide; trifluoromethylsulfonic anhydride; copper(II) sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;