5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline
CAS No.:132689-34-0
Molecular Formula:C₂₂H₂₅Cl₂N₃O₃
Molecular Weight:450.365
Hs Code.:

Synonyms:5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

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Chemical Property of 5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

There total 3 articles about 5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl trans-4-amino-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylate hydrochloride

: N,N'-dicyclohenxylcarbodiimide

: 99985-52-1
(4-dimethylaminomethyl-phenyl)-acetic acid

: 132689-34-0
5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: With benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 132691-22-6
ethyl 4-(N,N-dimethylaminomethyl)phenylacetate

: 132689-34-0
5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; water

2: benzotriazol-1-ol / tetrahydrofuran; dichloromethane; water; ethyl acetate

With benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 17841-69-9
ethyl 4-(aminomethyl)phenylacetate hydrochloride

: 132689-34-0
5,7-dichloro-4-[4-(N,N-dimethylaminomethyl)benzylcarbonylamino]-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: formaldehyd; sodium cyanoborohydride; sodium carbonate / water; acetonitrile

2: tetrahydrofuran; water

3: benzotriazol-1-ol / tetrahydrofuran; dichloromethane; water; ethyl acetate

With formaldehyd; sodium cyanoborohydride; sodium carbonate; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;