2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

Base Information

Chemical Name:2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide
CAS No.:89651-75-2
Molecular Formula:Br*C₂₄H₂₀N₃O₂
Molecular Weight:462.346
Hs Code.:

Synonyms:2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

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Chemical Property of 2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

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Technology Process of 2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

There total 6 articles about 2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 7-Benzyl-4-(1H-indol-2-yl)-4-methyl-4a,7-dihydro-4H-[2,7]naphthyridine-1,3-dione

: 89651-75-2
2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

Guidance literature:: With 10-benzylacridin-10-ium bromide; In acetonitrile; for 1h;
DOI:10.1016/S0040-4020(01)88606-3

Reference yield:

: 31271-90-6
1-(p-toluenesulfonyl)-1H-indole

: 89651-75-2
2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

Guidance literature:: Multi-step reaction with 6 steps

1: 58 percent / n-BuLi / tetrahydrofuran / 0.33 h

2: 56 percent / tetrahydrofuran / 2 h / Ambient temperature

3: 10percent Pd-C / ethanol / 760 Torr / Ambient temperature

4: NaOEt / tetrahydrofuran / 3 h / Ambient temperature

5: 60 percent / NaOEt / tetrahydrofuran / 5 h / Ambient temperature

6: 95 percent / N-benzylacridinium bromide / acetonitrile / 1 h

With palladium on activated charcoal; n-butyllithium; sodium ethanolate; 10-benzylacridin-10-ium bromide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/S0040-4020(01)88606-3

Reference yield:

: 89651-67-2
ethyl 2-(N-tosylindol-2-yl)acrylate

: 89651-75-2
2-Benzyl-5-(1H-indol-2-yl)-5-methyl-6,8-dioxo-5,6,7,8-tetrahydro-[2,7]naphthyridin-2-ium; bromide

Guidance literature:: Multi-step reaction with 4 steps

1: 10percent Pd-C / ethanol / 760 Torr / Ambient temperature

2: NaOEt / tetrahydrofuran / 3 h / Ambient temperature

3: 60 percent / NaOEt / tetrahydrofuran / 5 h / Ambient temperature

4: 95 percent / N-benzylacridinium bromide / acetonitrile / 1 h

With palladium on activated charcoal; sodium ethanolate; 10-benzylacridin-10-ium bromide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/S0040-4020(01)88606-3