2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE

Base Information

• Chemical Name: 2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE
• CAS No.: 1790-91-6
• Molecular Formula: C10H8Cl2N2O2
• Molecular Weight: 259.09
• Mol file: 1790-91-6.mol

Synonyms:2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE

Chemical Property of 2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE

Chemical Property:

• Vapor Pressure: 0.000204mmHg at 25°C
• Melting Point: 178 °C
• Refractive Index: 1.614
• Boiling Point: 337.5 °C at 760 mmHg
• PKA: -4.87±0.48(Predicted)
• Flash Point: 157.9 °C
• Density: 1.424 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloro-6,7-dimethoxyquinoxaline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE

There total 2 articles about 2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

6,7-dimethoxy-1,4-dihydro-quinoxaline-2,3-dione (4784-02-5) → 2,3-Dichloro-6,7-dimethoxyquinoxaline (1790-91-6)

Guidance literature:

With triethylamine; trichlorophosphate; for 18h; Reflux;

Reference yield:

→ 2,3-Dichloro-6,7-dimethoxyquinoxaline (1790-91-6)

Guidance literature:

/BRN= 746402/, POCl3;

Reference yield:

2,3-dichlorobenzenesulfonamide (82967-94-0) + 2,3-Dichloro-6,7-dimethoxyquinoxaline (1790-91-6) → 2,3-dichloro-N-(3-chloro-6,7-dimethoxyquinoxalin-2-yl)benzenesulfonamide

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 24h;

upstream raw materials:

6,7-dimethoxy-1,4-dihydro-quinoxaline-2,3-dione

Refernces

• 1、 -. "Novel [1,2,4]triazolo[4,3-a]quinoxaline amino phenyl derivatives or pharmaceutically acceptable salts thereof, preparation method therof and pharmaceutical composition for use in preventing or treating bromodomain extra-terminal(BET) protein activity related diseases containing the same as an active ingredient". Paragraph 0372-0375. . Retrieved 2018/12/12.