82967-94-0

Basic information

• Product Name: 2,3-Dichlorobenzenesulfonamide
• Synonyms: 2,3-Dichlorobenzenesulfonamide
• CAS NO: 82967-94-0
• Molecular Formula: C₆H₅Cl₂NO₂S
• Molecular Weight: 226.0804
• Mol File: 82967-94-0.mol

Chemical Properties

• Melting Point: >200°C
• Boiling Point: 393.8±52.0 °C(Predicted)
• Appearance: /
• Density: 1.588±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.39±0.60(Predicted)
• CAS DataBase Reference: 2,3-Dichlorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichlorobenzenesulfonamide(82967-94-0)
• EPA Substance Registry System: 2,3-Dichlorobenzenesulfonamide(82967-94-0)

Safety Data

• Hazardous Substances Data: 82967-94-0(Hazardous Substances Data)

Usage

Uses

2,3-Dichlorobenzenesulfonamide (>90%) can be used CCR4 antagonists.

Upstream product

• 82417-45-6 dichlorobenzenesulfonyl chloride 
• 1336-21-6 ammonium hydroxide 
• 608-27-5 2,3-dichloroaniline 

Downstream Products

• 204378-21-2 N-[(2,3-Dichlorophenyl)sulfonyl]-6-chloro-4-methoxypyridine-2-carboxamide 
• 68984-06-5 2,3-dichlorobenzenesulfonyl isocyanate 
• 1257328-43-0 C₂₀H₁₇Cl₃N₄O₂S 
• 1226503-21-4 2,3-dichloro-N-{3-[2,2,2-trifluoro-1-(1-methyl-1H-imidazol-2-yl)ethoxy]quinoxalin-2-yl}benzenesulfonamide 
• 1226504-41-1 2,3-dichloro-N-{3-[3-(pyridin-3-yl)propoxy]quinoxalin-2-yl}benzenesulfonamide 
• 1226505-21-0 2,3-dichloro-N-{3-[(pyridin-3-yl)methylamino]quinoxalin-2-yl}benzenesulfonamide 
• 1226505-22-1 2,3-dichloro-N-{3-[1-(pyridin-3-yl)ethylamino]quinoxalin-2-yl}benzenesulfonamide 
• 1226506-69-9 2,3-dichloro-N-(3-chloroquinoxalin-2-yl)benzenesulfonamide 
• 1429321-38-9 C₁₀H₁₂Cl₂N₂O₂S₂ 
• 1254305-62-8 C₁₅H₇Cl₃F₃N₃O₃S 

Relevant articles and documents

1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action

The synthesis of diversely substituted 3-alkyl/aralkyl/arylamino-1,4,2- benzodithiazine 1,1-dioxides and 3-alkylaminopyrido[4,3-e]-1,4,2-dithiazine 1,1-dioxides is described. Their biological activities on pancreatic β-cells and on smooth muscle cells were compared to those of the reference ATP-sensitive potassium channel (KATP channel) openers diazoxide and 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide. The aim was to assess the impact on biological activities of the replacement of the 1,2,4-thiadiazine ring by an isosteric 1,4,2-dithiazine ring. Most of the dithiazine analogues were found to be inactive on the pancreatic tissue, although some compounds bearing a 1-phenylethylamino side chain at the 3-position exerted a marked myorelaxant activity. Such an effect did not appear to be related to the opening of KATP channels but rather reflected a mechanism of action similar to that of calcium channel blockers. Tightly related 3-(1-phenylethyl)sulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides were also found to exert a pronounced myorelaxant activity, resulting from both a K ATP channel activation and a calcium channel blocker mechanism. The present work highlights the critical importance of an intracyclic NH group at the 4-position, as well as an exocyclic NH group linked to the 3-position of the benzo- and pyridothiadiazine dioxides, for activity on KATP channels.

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