{(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester

Base Information

• Chemical Name: {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester
• CAS No.: 213390-82-0
• Molecular Formula: C₃₅H₅₉O₈PSi
• Molecular Weight: 666.908

Synonyms:{(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester

Chemical Property of {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester

There total 4 articles about {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl (3-oxobutan-2-yl)phosphonate (117653-52-8) + tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane (213390-81-9) → {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester (213390-82-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydride; In tetrahydrofuran; 1.) 0 deg C, 90 min; 0 deg C, 30 min;, 2.) -78 deg C, 1 h;

DOI:10.1016/S0040-4039(98)01192-7

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester (213390-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 3 h / -78 °C

2: 95 percent / 1.) NaH; n-BuLi; 2.) HMPA / tetrahydrofuran / 1.) 0 deg C, 90 min; 0 deg C, 30 min;, 2.) -78 deg C, 1 h

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(98)01192-7

Reference yield:

(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-Iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dien-1-ol → {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester (213390-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 3 h / -78 °C

2: 95 percent / 1.) NaH; n-BuLi; 2.) HMPA / tetrahydrofuran / 1.) 0 deg C, 90 min; 0 deg C, 30 min;, 2.) -78 deg C, 1 h

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(98)01192-7

upstream raw materials:

diethyl (3-oxobutan-2-yl)phosphonate

tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

t-butyldimethylsiyl triflate

(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-Iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid methyl ester

Downstream raw materials:

C₆₀H₁₀₄O₉Si₂

C₆₆H₁₂₀O₉Si₃

(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

(3E,5E,13E,19E)-(1R,9S,10R,11S,15R,17R,21S,24R,25R,27S,29R)-11-Hydroxy-15,21-dimethoxy-27-(4-methoxy-phenyl)-10,17,20,24,29-pentamethyl-9-((S)-1-methyl-2-triisopropylsilanyloxy-ethyl)-8,26,28-trioxa-bicyclo[23.3.1]nonacosa-3,5,13,19-tetraen-7-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 213390-82-0 {(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send