tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

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Chemical Name:tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane
CAS No.:213390-81-9
Molecular Formula:C₂₇H₄₃IO₄Si
Molecular Weight:586.626
Hs Code.:

Synonyms:tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

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Chemical Property of tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

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Technology Process of tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

There total 2 articles about tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: (2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-Iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dien-1-ol

: 213390-81-9
tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 3h; Yield given;
DOI:10.1016/S0040-4039(98)01192-7

Reference yield:

: 213385-31-0
(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-Iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid methyl ester

: 213390-81-9
tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL / CH₂Cl₂ / 2 h / -78 °C

2: 2,6-lutidine / CH₂Cl₂ / 3 h / -78 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1016/S0040-4039(98)01192-7

Reference yield: 95.0%

: 117653-52-8
diethyl (3-oxobutan-2-yl)phosphonate

: 213390-81-9
tert-Butyl-{(2E,4E)-6-[(2S,4R,5R,6S)-6-((S)-2-iodo-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienyloxy}-dimethyl-silane

: 213390-82-0
{(R)-5-[(2S,4R,5R,6R)-6-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-2-oxo-hexyl}-phosphonic acid diethyl ester

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydride; In tetrahydrofuran; 1.) 0 deg C, 90 min; 0 deg C, 30 min;, 2.) -78 deg C, 1 h;
DOI:10.1016/S0040-4039(98)01192-7