(2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

Base Information

Chemical Name:(2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol
CAS No.:131227-82-2
Molecular Formula:C₄₁H₄₃NO₅
Molecular Weight:629.796
Hs Code.:

Synonyms:(2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

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Chemical Property of (2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

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Technology Process of (2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

There total 16 articles about (2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 596-43-0
bromo-triphenyl-methane

: (2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3-ol

: 131227-82-2
(2R,3S,4R,5R,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

Guidance literature:: In pyridine; at 80 ℃; for 12h;
DOI:10.1016/S0040-4020(01)87751-6

Reference yield:

: 2567-29-5
p-phenylbenzyl bromide

: 131227-82-2
(2R,3S,4R,5S,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.)NaH / 1.)THF/DMF, r.t.

2: 1N HCl / methanol / 70 °C

3: pyridine / 80 °C

With pyridine; hydrogenchloride; sodium hydride; In methanol;
DOI:10.1016/S0040-4020(01)87751-6

Reference yield:

: [(2S,3S,4R,5S,6R)-4,5-Bis-(biphenyl-4-ylmethoxy)-2-methoxy-6-trityloxymethyl-tetrahydro-pyran-3-yl]-dimethyl-amine

: 131227-82-2
(2R,3S,4R,5S,6S)-4-(Biphenyl-4-ylmethoxy)-5-dimethylamino-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 1N HCl / methanol / 70 °C

2: p-toluenesulfonic acid / dimethylformamide / 80 °C

3: 1.)NaH / 1.)THF/DMF, r.t.

4: 1N HCl / methanol / 70 °C

5: pyridine / 80 °C

With pyridine; hydrogenchloride; sodium hydride; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87751-6