[7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Base Information

Chemical Name:[7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine
CAS No.:867331-58-6
Molecular Formula:C₂₇H₂₈N₆O₄
Molecular Weight:500.557
Hs Code.:

Synonyms:[7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

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Chemical Property of [7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

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Technology Process of [7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

There total 5 articles about [7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 867330-99-2
7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-ylamine

: 1081-73-8
1-[2-(4-bromophenoxy)ethyl]pyrrolidine

: 867331-58-6
[7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane-d8; for 4h; Heating / reflux;

Reference yield:

: 119707-95-8
2-nitro-4-bromophenylguanidine

: 867331-58-6
[7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / 0.5 h / 110 °C

2: 95 percent / HNO₃; H₂SO₄ / 16 h / 22 °C

3: 80 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / Heating

4: Pd₂(dba)3; xanthos; Cs₂CO₃ / dioxane / 12 h / Heating

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; xanthos; sulfuric acid; nitric acid; potassium carbonate; caesium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.11.006

Reference yield:

: 867330-98-1
7-bromo-5-nitro-1-oxy-benzo[1,2,4]triazin-3-ylamine

: 867331-58-6
[7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / Heating

2: Pd₂(dba)3; xanthos; Cs₂CO₃ / dioxane / 12 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; xanthos; potassium carbonate; caesium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.11.006