(3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Base Information

Chemical Name:(3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol
CAS No.:156768-17-1
Molecular Formula:C₁₉H₂₆O₆
Molecular Weight:350.412
Hs Code.:

Synonyms:(3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Suppliers and Price of (3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

There total 13 articles about (3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176200-07-0
(3aS,4S,4aR,7aR,8S,8aR)-4,8-Bis-benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxole

: 156558-38-2
D-(-)-1,2:4,5-di-O-isopropylidene-myo-inositol

: 156768-17-1
(3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Guidance literature:: With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 72h; under 760.051 Torr;
DOI:10.1080/07328300701540225

Reference yield:

: (3aS,4aS,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-tetrahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-one

: 156768-17-1
(3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at -78 ℃; Yield given;
DOI:10.1021/jo00088a003

Reference yield:

: 100-39-0
benzyl bromide

: 156768-17-1
(3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 91.3 percent / NaH; TBAI / tetrahydrofuran / 0 - 20 °C

2: 89.2 percent / NMO / OsO₄ / acetone; H₂O / 12 h / 20 °C

3: TSA / CH₂Cl₂ / 1 h / 20 °C

4: 2.0 g / H₂; NaHCO₃ / Pd/C / tetrahydrofuran / 72 h / 20 °C / 760.05 Torr

With N-methyl-2-indolinone; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1080/07328300701540225