C₂₈H₃₄O₈Si

Base Information

• Chemical Name: C₂₈H₃₄O₈Si
• CAS No.: 491580-67-7
• Molecular Formula: C₂₈H₃₄O₈Si
• Molecular Weight: 526.659
• Mol file: 491580-67-7.mol

Synonyms:C₂₈H₃₄O₈Si

Chemical Property of C₂₈H₃₄O₈Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₄O₈Si

There total 5 articles about C₂₈H₃₄O₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4'-O-tert-butyldimethylsilanyl-4'-O-demethyl-4-deoxy-4-methylene-podophyllotoxin (491580-65-5) → C28H34O8Si (491580-67-7)

Guidance literature:

With silver(II) oxide; iodine; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

DOI:10.1016/S0968-0896(02)00255-9

Reference yield:

4'-demethylepipodophyllotoxin (6559-91-7) → C28H34O8Si (491580-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 86 percent / imidazole / dimethylformamide / 4.5 h

2.1: 88 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.33 h

3.1: zinc / tetrahydrofuran / 0.5 h / 20 °C

3.2: TiCl₄ / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

3.3: 73 percent / tetrahydrofuran; CH₂Cl₂ / 20 h / 20 °C

4.1: 87 percent / iodine; silver(II) oxide / H₂O; tetrahydrofuran / 0.33 h / 20 °C

With 1H-imidazole; silver(II) oxide; iodine; Dess-Martin periodane; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Dess-Martin oxidation / 3.3: Takai olefination;

DOI:10.1016/S0968-0896(02)00255-9

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → C28H34O8Si (491580-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 86 percent / imidazole / dimethylformamide / 4.5 h

2.1: 88 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.33 h

3.1: zinc / tetrahydrofuran / 0.5 h / 20 °C

3.2: TiCl₄ / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

3.3: 73 percent / tetrahydrofuran; CH₂Cl₂ / 20 h / 20 °C

4.1: 87 percent / iodine; silver(II) oxide / H₂O; tetrahydrofuran / 0.33 h / 20 °C

With 1H-imidazole; silver(II) oxide; iodine; Dess-Martin periodane; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Dess-Martin oxidation / 3.3: Takai olefination;

DOI:10.1016/S0968-0896(02)00255-9

upstream raw materials:

4'-O-tert-butyldimethylsilanyl-4'-O-demethyl-4-deoxy-4-methylene-podophyllotoxin

4'-demethylepipodophyllotoxin

tert-butyldimethylsilyl chloride

4'-O-tert-butyldimethylsilanyl-4'-O-demethyl-4-epipodophyllotoxin