4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

Base Information

Chemical Name:4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide
CAS No.:1335094-55-7
Molecular Formula:C₁₆H₁₂BF₄NO₃
Molecular Weight:353.081
Hs Code.:

Synonyms:4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

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Chemical Property of 4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

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Technology Process of 4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

There total 5 articles about 4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335095-08-3
7-amino-3,4-dihydro-1H-2,1-benzoxaborinin-1-ol

: 189807-21-4
2-trifluoromethyl-4-fluorobenzoyl chloride

: 1335094-55-7
4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

Guidance literature:: 7-amino-3,4-dihydro-1H-2,1-benzoxaborinin-1-ol; 2-trifluoromethyl-4-fluorobenzoyl chloride; With triethylamine; at 20 ℃;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 1074-16-4
2-bromophenylethyl alcohol

: 1335094-55-7
4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: nitric acid / 0.17 h / -45 - -40 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran

5.1: triethylamine / 20 °C

With n-butyllithium; camphor-10-sulfonic acid; hydrogen; nitric acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane;

Reference yield:

: 143888-88-4
2-(2-bromophenyl)ethyl tetrahydro-2H-pyran-2-yl ether

: 1335094-55-7
4-fluoro-N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-7-yl)-2-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: nitric acid / 0.17 h / -45 - -40 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran

4.1: triethylamine / 20 °C

With n-butyllithium; hydrogen; nitric acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran;