3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

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Chemical Name:3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole
CAS No.:1262848-97-4
Molecular Formula:C₁₉H₁₄F₃N₅O₂S
Molecular Weight:433.414
Hs Code.:

Synonyms:3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

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Chemical Property of 3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

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Technology Process of 3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

There total 5 articles about 3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 142-08-5
2-hydroxypyridin

: 1262848-95-2
5-chloro-3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-thiadiazole

: 1262848-97-4
3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

Guidance literature:: With silver carbonate; In acetonitrile; at 180 ℃; for 0.75h;

Reference yield:

: 155377-19-8
ethyl 5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1262848-97-4
3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 4.5 h / Reflux

2: ammonium chloride; trimethylaluminum / n-heptane; toluene / -5 - 80 °C / Inert atmosphere

3: sodium hydroxide / dichloromethane; water / 72.5 h / -5 - 20 °C

4: silver carbonate / acetonitrile / 0.75 h / 180 °C

With trimethylaluminum; potassium carbonate; ammonium chloride; silver carbonate; sodium hydroxide; In n-heptane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1105039-92-6
ethyl 1-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)pyrazole-4-carboxylate

: 1262848-97-4
3-(1-(4-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(pyridin-2-yloxy)-1,2,4-thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; trimethylaluminum / n-heptane; toluene / -5 - 80 °C / Inert atmosphere

2: sodium hydroxide / dichloromethane; water / 72.5 h / -5 - 20 °C

3: silver carbonate / acetonitrile / 0.75 h / 180 °C

With trimethylaluminum; ammonium chloride; silver carbonate; sodium hydroxide; In n-heptane; dichloromethane; water; toluene; acetonitrile;