4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE

Base Information

• Chemical Name: 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE
• CAS No.: 19152-39-7
• Molecular Formula: C16H12O4
• Molecular Weight: 268.269
• Hs Code.: 2932999099
• Mol file: 19152-39-7.mol

Synonyms:Chalcone,4'-hydroxy-3,4-(methylenedioxy)- (8CI);NSC 667227;1-(4-Hydroxyphenyl)-3-(3,4-methylenedioxyphenyl)-2-propen-1-one;

Chemical Property of 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE

Chemical Property:

• Boiling Point: 482.6 °C at 760 mmHg
• Flash Point: 184.8 °C
• PSA: 55.76000
• Density: 1.345 g/cm³
• LogP: 3.01700

Purity/Quality:

98%Min ^*data from raw suppliers

4'-Hydroxy-3,4-(methylenedioxy)chalcone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE

There total 3 articles about 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

piperonal (120-57-0,30024-74-9) + 4-Hydroxyacetophenone (99-93-4) → (E)-3-(benzo[d][1,3]dioxol-5-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one (19152-39-7)

Guidance literature:

With sodium hydroxide; In ethanol; for 1.5h; Ambient temperature;

DOI:10.1021/jm9606507

Reference yield:

piperonal (120-57-0,30024-74-9) + 4-Hydroxyacetophenone (99-93-4) → 3: two linear bonds on the same side of stereo double bond (19152-39-7)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1016/j.bmcl.2011.03.057

Reference yield:

→ 3: two linear bonds on the same side of stereo double bond (19152-39-7)

Guidance literature:

4-Hydroxy-acetophenon, Piperonal;

upstream raw materials:

piperonal

4-Hydroxyacetophenone

Downstream raw materials:

4-(3-(benzo[d][1,3]dioxol-5-yl)propyl)phenol

4'-(2-hydroxy-ethoxy)-3,4-methylenedioxy-trans-chalcone

2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyronitrile

Refernces

• 1、 Baby, Bency,Dev, Sanal,Joy, Monu,Magdy, Hendawy Omnia,Mathew, Bijo,Mathew, Githa Elizabeth,Parambi, Della Grace Thomas,Sudev, Shine. "An environment-friendly synthesis of piperonal chalcones and their cytotoxic and antioxidant evaluation". . p. 138 - 144. Retrieved 2020/02/29.
• 2、 Vijaya Bhaskar Reddy, Mopur,Hung, Hsin-Yi,Kuo, Ping-Chung,Huang, Guan-Jhong,Chan, Yu-Yi,Huang, Shiow-Chyn,Wu, Shwu-Jen,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung,Wu, Tian-Shung. "Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents". supporting information. p. 1547 - 1550. Retrieved 2017/03/17.