2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

Base Information

Chemical Name:2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester
CAS No.:169804-36-8
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.402
Hs Code.:

Synonyms:2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

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Chemical Property of 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

Chemical Property:

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Technology Process of 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

There total 5 articles about 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 67-56-1
methanol

: 169804-35-7
2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyronitrile

: 169804-36-8
2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; Heating;
DOI:10.1021/jm9606507

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 169804-36-8
2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / 10percent aq. NaOH / ethanol / 1.5 h / Ambient temperature

2: 79 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

3: 89 percent / AcOH / H₂O; 2-ethoxy-ethanol / 0.5 h / 105 °C

4: 73 percent / p-toluenesulfonic acid hydrate / dioxane / Heating

With sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In 1,4-dioxane; 2-ethoxy-ethanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9606507

Reference yield:

: 19152-39-7
(E)-3-(benzo[d][1,3]dioxol-5-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one

: 169804-36-8
2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

2: 89 percent / AcOH / H₂O; 2-ethoxy-ethanol / 0.5 h / 105 °C

3: 73 percent / p-toluenesulfonic acid hydrate / dioxane / Heating

With potassium carbonate; toluene-4-sulfonic acid; acetic acid; In 1,4-dioxane; 2-ethoxy-ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9606507