cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester
CAS No.:518994-62-2
Molecular Formula:C₂₅H₃₁NO₄
Molecular Weight:409.525
Hs Code.:

Synonyms:cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Chemical Property of cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Technology Process of cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

There total 4 articles about cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-39-0
benzyl bromide

: 518994-85-9
(2R',5S')-tert-butyl 2,5-bis(hydroxymethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate

: 518994-62-2
cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol027504h

Reference yield:

: 5176-27-2
N-tert-butyloxycarbonyl-pyrrole

: 518994-62-2
cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium 2,2,6,6-tetramethylpiperidide / tetrahydrofuran; hexane / 3 h / cooling

1.2: 78 percent / tetrahydrofuran; hexane / 0.5 h / cooling

2.1: lithium; liq. ammonia / tetrahydrofuran / 0.5 h / cooling

2.2: isoprene / tetrahydrofuran

2.3: ammonium chloride / tetrahydrofuran

3.1: 65 percent / lithium borohydride / tetrahydrofuran / 1 h / 20 °C

4.1: 95 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 20 °C

With lithium borohydride; 2,2,6,6-tetramethylpiperidinyl-lithium; ammonia; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/ol027504h

Reference yield:

: 473401-82-0
pyrrole-1,2,5-tricarboxylic acid 1-tert-butyl ester 2,5-dimethyl ester

: 518994-62-2
cis-2,5-bis-benzyloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium; liq. ammonia / tetrahydrofuran / 0.5 h / cooling

1.2: isoprene / tetrahydrofuran

1.3: ammonium chloride / tetrahydrofuran

2.1: 65 percent / lithium borohydride / tetrahydrofuran / 1 h / 20 °C

3.1: 95 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 20 °C

With lithium borohydride; ammonia; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ol027504h