1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID
• CAS No.: 137088-51-8
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.293
• Hs Code.: 2933998090
• Mol file: 137088-51-8.mol

Synonyms:Indoline-2-carboxylic acid, N-BOC protected;

Chemical Property of 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID

Chemical Property:

• Melting Point: 121-122
• Boiling Point: 411.6°Cat760mmHg
• PKA: 3.85±0.20(Predicted)
• Flash Point: 202.7°C
• PSA: 66.84000
• Density: 1.259g/cm³
• LogP: 2.50240
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)indoline-2-carboxylicacid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID

There total 2 articles about 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + indolin-2-yl carboxylic acid (16851-56-2,78348-24-0) → 1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid (137088-51-8,133851-52-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; for 2h;

DOI:10.1016/j.bmcl.2010.06.004

Reference yield: 80.6%

indolin-2-yl carboxylic acid (16851-56-2,78348-24-0) → 1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid (137088-51-8,133851-52-2)

Guidance literature:

With triethanolamine; In tetrahydrofuran;

Reference yield: 95.0%

benzyl bromide (100-39-0) + 1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid (137088-51-8,133851-52-2) → 2,3-dihydro-indole-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (252357-58-7)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

upstream raw materials:

di-tert-butyl dicarbonate

indolin-2-yl carboxylic acid

Downstream raw materials:

2-(methoxymethyl)indoline

N-(t-butoxycarbonyl)-2-(methoxymethyl)indoline

2,3-dihydro-indole-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

C₂₁H₂₁F₃N₂O₃