5-(BOC-AMINO)-1-PENTANOL

Base Information

• Chemical Name: 5-(BOC-AMINO)-1-PENTANOL
• CAS No.: 75178-90-4
• Molecular Formula: C10H21NO3
• Molecular Weight: 203.282
• Hs Code.: 2924199090
• Mol file: 75178-90-4.mol

Synonyms:Carbamicacid, (5-hydroxypentyl)-, 1,1-dimethylethyl ester (9CI);1,1-Dimethylethyl(5-hydroxypentyl)carbamate;5-(Boc-amino)pentan-1-ol;5-(N-tert-Butoxycarbonyl)amino-1-pentanol;5-(tert-Butoxycarbonyl)amino-1-pentanol;5-[[(t-Butyloxy)carbonyl]amino]pentanol;N-(tert-Butoxycarbonyl)-5-aminopentanol;tert-Butyl (5-hydroxypentyl)carbamate;

Chemical Property of 5-(BOC-AMINO)-1-PENTANOL

Chemical Property:

• Appearance/Colour: Pale Yellow Oil
• Vapor Pressure: 3E-05mmHg at 25°C
• Refractive Index: n20/D 1.45
• Boiling Point: 318.4 °C at 760 mmHg
• PKA: 12.88±0.46(Predicted)
• Flash Point: 146.3 °C
• PSA: 58.56000
• Density: 0.999 g/cm³
• LogP: 2.06460
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• Water Solubility.: Difficult to mix in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(t-Boc-amino)-1-pentanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: 5-(Boc-amino)-1-pentanol is a linker containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
• Uses: Linker (anthraquinone-oligopeptide) 5-(Boc-amino)-1-pentanol may also be used as non-limiting linkers.

Technology Process of 5-(BOC-AMINO)-1-PENTANOL

There total 6 articles about 5-(BOC-AMINO)-1-PENTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-hydroxypentylamine (2508-29-4) + di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butyloxycarbonyl)-5-aminopentanol (75178-90-4)

Guidance literature:

In dichloromethane; for 12h;

DOI:10.1055/s-1990-26879

Reference yield: 100.0%

5-hydroxypentylamine (2508-29-4) + tert-butyldicarbonate (34619-03-9) → N-(tert-butyloxycarbonyl)-5-aminopentanol (75178-90-4)

Guidance literature:

In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.bmcl.2013.01.092

Reference yield: 99.0%

2-oxopiperidine-1-carboxylic acid tert-butyl ester (85908-96-9) → N-(tert-butyloxycarbonyl)-5-aminopentanol (75178-90-4)

Guidance literature:

With Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen; In tert-butyl alcohol; at 80 ℃; for 24h; under 22502.3 Torr; Autoclave;

DOI:10.1002/anie.200805307

upstream raw materials:

5-hydroxypentylamine

di-tert-butyl dicarbonate

5-(N-tert-butyloxycarbonyl)aminopentanoic acid

2-oxopiperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

2-bromo-5-[5-(tert-butyl-diphenyl-silanyloxy)-pentylamino]-pent-2-enoic acid methyl ester