Technology Process of 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-6-fluoro-2-oxoindoline-5-carboxylic acid
There total 6 articles about 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-6-fluoro-2-oxoindoline-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
1.2: 0 - 20 °C
2.1: nickel / methanol
3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C
4.1: toluene-4-sulfonic acid / toluene / 2 h / Heating / reflux
5.1: methanol; sodium hydroxide; water / 1.5 h / 80 °C
5.2: 20 °C
5.3: Amberlite IRA-400 (Cl) ion exchange resin
With
methanol; sodium hydroxide; water; sodium tris(acetoxy)borohydride; sodium hydride; toluene-4-sulfonic acid; acetic acid;
nickel;
In
methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nickel / methanol
2.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C
3.1: toluene-4-sulfonic acid / toluene / 2 h / Heating / reflux
4.1: methanol; sodium hydroxide; water / 1.5 h / 80 °C
4.2: 20 °C
4.3: Amberlite IRA-400 (Cl) ion exchange resin
With
methanol; sodium hydroxide; water; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; acetic acid;
nickel;
In
methanol; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / Heating / reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
2.2: 0 - 20 °C
3.1: nickel / methanol
4.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C
5.1: toluene-4-sulfonic acid / toluene / 2 h / Heating / reflux
6.1: methanol; sodium hydroxide; water / 1.5 h / 80 °C
6.2: 20 °C
6.3: Amberlite IRA-400 (Cl) ion exchange resin
With
methanol; sodium hydroxide; sulfuric acid; water; sodium tris(acetoxy)borohydride; sodium hydride; toluene-4-sulfonic acid; acetic acid;
nickel;
In
methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
