tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate

Base Information

• Chemical Name: tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate
• CAS No.: 402509-10-8
• Molecular Formula: C₃₇H₅₄ClN₃O₅SSi
• Molecular Weight: 716.457
• Mol file: 402509-10-8.mol

Synonyms:tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate

Chemical Property of tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate

There total 9 articles about tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-[2-(4-aminophenyl)ethyl]-4-methylbenzenesulfonamide (111437-08-2) + 1,1-dimethylethyl ((2R)-2-(3-chlorophenyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)[(1R)-1-methyl-2-oxoethyl]carbamate (174891-03-3) → tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate (402509-10-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0101500

Reference yield:

2-(4-nitrophenyl)ethylamine monohydrochloride (29968-78-3) → tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate (402509-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 33 percent / Et₃N / CH₂Cl₂ / 20 h / 20 °C

2: 40 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 20 °C / 760.05 Torr

3: 90 percent / NaBH(OAc)3; AcOH / CH₂Cl₂ / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; 10percent Pd/C; In ethanol; dichloromethane;

DOI:10.1021/jm0101500

Reference yield:

N-[2-(4-nitrophenyl)ethyl]-4-methylbenzenesulfonamide (111437-16-2) → tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl{(1R)-1-methyl-2-[4-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)anilino]ethyl}carbamate (402509-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 20 °C / 760.05 Torr

2: 90 percent / NaBH(OAc)3; AcOH / CH₂Cl₂ / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 10percent Pd/C; In ethanol; dichloromethane;

DOI:10.1021/jm0101500

upstream raw materials:

N-[2-(4-aminophenyl)ethyl]-4-methylbenzenesulfonamide

1,1-dimethylethyl ((2R)-2-(3-chlorophenyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)[(1R)-1-methyl-2-oxoethyl]carbamate

di-tert-butyl dicarbonate

N-[2-(4-nitrophenyl)ethyl]-4-methylbenzenesulfonamide