ClopidogrelAmide-d4

Base Information

Chemical Name:ClopidogrelAmide-d4
CAS No.:90055-68-8
Molecular Formula:C₁₅H₁₅ClN₂OS
Molecular Weight:306.816
Hs Code.:
UNII:32LR8TZ2SB

Synonyms:ClopidogrelAmide-d4;90055-68-8;32LR8TZ2SB;SCHEMBL2086123;SRKXAUBVRPEIQR-UHFFFAOYSA-N;CS-0165256;CLOPIDOGREL BESILATE IMPURITY E [EP IMPURITY];CLOPIDOGREL HYDROCHLORIDE IMPURITY E [EP IMPURITY];(+)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide;(+/-)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide;2-Chlorophenyl-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide;alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetamide;(+)-(2-Chlorophenyl) (6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide;(+/-)-(2-chloro-phenyl)(6,7-dihydro-4h-thieno[3,2-c]pyrid-5-yl)acetamide;(+/-)-(2-chloro-phenyl)-(6,7-dihydro-4h-thieno[3,2-c]pyrid-5-yl) acetamide;(+/-)-(2-chloro-phenyl)-(6,7-dihydro-4h-thieno[3,2-c]pyrid-5-yl)acetamide;(+/-)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide;(+/-)-2-(2-Chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide;(2RS)-2-(2-CHLOROPHENYL)-2-(6,7-DIHYDROTHIENO(3,2-C)PYRIDIN-5(4H)-YL)ACETAMIDE;Thieno[3,2-c]pyridine-5(4H)-acetamide, alpha-(2-chlorophenyl)-6,7-dihydro-;2-(2-CHLOROPHENYL)-2-(6,7-DIHYDROTHIENO(3,2-C)PYRIDIN-5(4H)-YL)ACETAMIDE, (+/-)-;2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetamide? (Clopidogrel Impurity pound(c)

Suppliers and Price of ClopidogrelAmide-d4

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of ClopidogrelAmide-d4

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:306.0593620
Heavy Atom Count:20
Complexity:368

Purity/Quality:: 95+%HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CC2=C1SC=C2)C(C3=CC=CC=C3Cl)C(=O)N

Technology Process of ClopidogrelAmide-d4

There total 3 articles about ClopidogrelAmide-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 444728-11-4
2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile

: 90055-68-8
(+/-)-methyl-(2-chlorophenyl)-(4,5,6,7-4H-thieno[3,2,-c]pyrid-5-yl) acetamide

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In methanol; water; for 12h; Reflux; Green chemistry;
DOI:10.1021/op700025d

Reference yield:

: 444891-19-4
2-bromo-2-(2-chlorophenyl)acetonitrile

: 90055-68-8
(+/-)-methyl-(2-chlorophenyl)-(4,5,6,7-4H-thieno[3,2,-c]pyrid-5-yl) acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / methanol / 3 h / Reflux; Green chemistry

2: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / methanol; water / 12 h / Reflux; Green chemistry

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; sodium hydroxide; In methanol; water;
DOI:10.1021/op700025d

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 90055-68-8
(+/-)-methyl-(2-chlorophenyl)-(4,5,6,7-4H-thieno[3,2,-c]pyrid-5-yl) acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / neat (no solvent) / 6 h / 105 - 110 °C / Green chemistry

2: sodium hydrogencarbonate / methanol / 3 h / Reflux; Green chemistry

3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / methanol; water / 12 h / Reflux; Green chemistry

With N-benzyl-N,N,N-triethylammonium chloride; bromine; sodium hydrogencarbonate; sodium hydroxide; In methanol; water;
DOI:10.1021/op700025d