444891-19-4

Basic information

• Product Name: Benzeneacetonitrile, .alpha.-broMo-2-chloro-
• Synonyms: Benzeneacetonitrile, .alpha.-broMo-2-chloro-;2-Bromo-2-(2-chlorophenyl)acetonitrile
• CAS NO: 444891-19-4
• Molecular Formula: C₈H₅BrClN
• Molecular Weight: 230.489
• Mol File: 444891-19-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 260.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.628±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzeneacetonitrile, .alpha.-broMo-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, .alpha.-broMo-2-chloro-(444891-19-4)
• EPA Substance Registry System: Benzeneacetonitrile, .alpha.-broMo-2-chloro-(444891-19-4)

Safety Data

• Hazardous Substances Data: 444891-19-4(Hazardous Substances Data)

Usage

General Description

Benzeneacetonitrile, alpha-bromo-2-chloro- is a chemical compound with the molecular formula C8H6BrClN. It is a colorless liquid at room temperature and is commonly used as a reagent in organic synthesis. Benzeneacetonitrile, .alpha.-broMo-2-chloro- is characterized by the presence of both bromine and chlorine atoms, as well as a nitrile functional group, which gives it a diverse range of chemical reactivity. It is commonly used in the pharmaceutical and fine chemical industries for the synthesis of various organic compounds and is also known for its use as a precursor in the synthesis of pharmaceutical drugs and agrochemicals. Due to its reactivity and potential hazards, it should be handled with care and proper safety measures.

Upstream product

• 2856-63-5 2-Chlorophenylacetonitrile 

Downstream Products

• 444728-11-4 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile 
• 90055-68-8 (+/-)-methyl-(2-chlorophenyl)-(4,5,6,7-4H-thieno[3,2,-c]pyrid-5-yl) acetamide 
• 120202-66-6 (S)-(+)-clopidogrel bisulfate 
• 144457-28-3 SR 26334 
• 90055-55-3 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid 
• 1147350-77-3 cis-5-thiol metabolite 
• 113665-84-2 (S)-(+)-clopidogrel 
• 90055-48-4 clopidogrel 

Relevant articles and documents

Prodrugs of anti-platelet agents

The invention relates to the compounds of formula I, formula II, formula Ia, formula IIb or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula Ia, formula IIb and methods for treating or preventing atherothrombosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment or management of ischemia, stroke, cerebral thrombosis, arterial thrombosis, thrombotic cerebrovascular, cardiovascular diseases and blood clots.

PRODRUGS OF ANTI-PLATELET AGENTS

Disclosed is the compounds of formula (I), formula (II), formula (la), formula (IIb) or its pharmaceutical acceptable salts, polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising and effective amount of formula (I), formula (II), formula (la), formula (lIb) and may be used to treatment or management of ischemia, stroke, cerebral thrombosis, arterial thrombosis, thrombotic cerebrovascular, cardiovasculard diseases and blood colts.

PREPARATION OF CLOPIDOGREL AND ITS ANALOGUES METHYL TETRAHYDROTHIENOPYRIDINE ACETATE COMPOUNDS

The present invention disclosed a preparation method of Clopidogrel (X=2-Cl) and its analogues of methyl tetrahydrothienopyridine acetate (I) by using halogen phenyl acetonitrile (VIII) as starting material and tetrahydrothienopyridine acetonitrile (IV), tetrahydrothienopyridine acetate (V) as key intermediates, and further using kinetic resolution to prepare the optical active Clopidogrel and compounds of methyl tetrahydrothenopridine acetate of formula (XII). The Clopidogrel of present invention is a novel high effective and safety drug for inhibition of platelet aggregation. This invention applied systematic technique of racemization of unwanted optical active enantiomer, recover recycle and reuse of resolution agent etc., with greater economic advantages and suitable for commercial scale industrial production. Wherein: X represents atoms of hydrogen, fluorine, chlorine, bromine or iodine, M represents an alkali metal ion.