(S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:(S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide
CAS No.:1187465-75-3
Molecular Formula:C₁₉H₂₀F₄N₄O₂S
Molecular Weight:444.453
Hs Code.:

Synonyms:(S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

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Chemical Property of (S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

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Technology Process of (S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

There total 3 articles about (S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187465-74-2
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-2-fluoro-5-(trifluoromethyl)benzamide

: 51693-17-5
(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester

: 1187465-75-3
(S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

Guidance literature:: With tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In toluene; for 14h; Reflux;

Reference yield:

: 207981-46-2
2-fluoro-5-(trifluoromethyl)benzoyl chloride

: 1187465-75-3
(S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; potassium carbonate / toluene / 14 h / Reflux

With tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In dichloromethane; toluene;

Reference yield:

: 39222-73-6
2-Amino-5-t-butyl-1,3,4-thiadiazole

: 1187465-75-3
(S,Z)-N-(5-tert-butyl-3-((5-oxopyrrolidin-2-yl)methyl)-1,3,4-thiadiazol-2(3H)-ylidene)-2-fluoro-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; potassium carbonate / toluene / 14 h / Reflux

With tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In dichloromethane; toluene;