(+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate

Base Information

Chemical Name:(+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate
CAS No.:1312025-95-8
Molecular Formula:C₂₄H₃₆N₂O₄S₂
Molecular Weight:480.693
Hs Code.:

Synonyms:(+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate

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Chemical Property of (+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate

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Technology Process of (+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate

There total 2 articles about (+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 169140-88-9,1071508-47-8,1071508-50-3
(-)-(R)-O-3-phenyl-1-(tri-n-butylstannyl)propyl pyrrolidine-1-carbothioate

: 1312025-85-6
(-)-(S)-S-4-nitrophenyl 2-(tert-butoxycarbonyl)amino-4-(methylthio)butanethioate

: 1312025-95-8
(+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate

Guidance literature:: With copper(I) thiophene-2-carboxylate; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;
DOI:10.1021/ol201330j

Reference yield:

: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

: 1312025-95-8
(+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24.25 h / 0 - 20 °C

2: copper(I) thiophene-2-carboxylate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With copper(I) thiophene-2-carboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ol201330j