Technology Process of 676501-63-6
There total 3 articles about 676501-63-6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-amino-3-methylbutane; 6-(4-formylphenoxy)-N-isopropylnicotinamide;
With
sodium sulfate;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ja4126609
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; lithium tert-butoxide / acetonitrile; N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere
1.2: 9 h / 20 °C / Inert atmosphere; Irradiation
2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 125 °C / Inert atmosphere; Glovebox; Sealed tube
3.1: sodium sulfate / dichloromethane / 4 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
With
copper(l) iodide; caesium carbonate; sodium sulfate; lithium tert-butoxide;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja4126609
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 125 °C / Inert atmosphere; Glovebox; Sealed tube
2.1: sodium sulfate / dichloromethane / 4 h / 20 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
With
caesium carbonate; sodium sulfate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja4126609
